Different experimental approaches pointed to a potent translocation of AGO2 into the nucleus in SHSY5Y neuroblastoma, A375 melanoma cells, HEK293 kidney cells, and U2OS bone cancer cells upon silencing of LMNA expression (Figure 1E, F, Figure 2G, H, Supplemental Figure S1B, C). The gene discussed is LMNA; the disease is bone cancer.