HMGCS1 and plasma cell myeloma: As an upstream enzyme in the de novo cholesterol synthesis pathway, HMGCS1 has been reported to enhance tumor growth in melanoma.17 HMGCS1 was also upregulated in multiple myeloma (MM) cells insensitive to statins18 and AML cells treated with statins.19 However, the specific role of HMGCS1 in AML has not been reported yet.