On average, 24 hours after DENV enters the body, the immune system begins to develop its response, initially based on the production of IgM, detectable for diagnostic support after the 5th day of clinical manifestations of dengue.(56) The production of IgG is normally detectable after 14 days, although the onset of IgG production can sometimes be anticipated. The gene discussed is CD40LG; the disease is dengue disease.