PTCH1 and neoplasm: Tumor cell proliferation is reduced, with decreased accumulation of G1 phase cells and inhibition of DNA and RNA synthesis.Reduced protein expression levels of β-conjugated proteins, patched1 (Ptch1), and glioma-associated oncogene homologous zinc finger protein 1 (Gli1) were found.The protein expression levels of cell cycle protein D1 and c-Myc were reduced.