The biomarkers represented here were investigated in our previous studies and are based on the RGC-32 interactome, being major proteins interacting with or being regulated by RGC-32, a molecule which has been shown to play a major role in cell cycle regulation and differentiation, including in cells with critical role in neuroinflammation and MS pathogenesis such as CD4+ T cells and astrocytes (Supplementary Figure 1) (26, 27). Here, CD4 is linked to myeloid sarcoma.