In conclusion, TB patients previously infected with SARS-CoV-2 demonstrated an immunomodulation that conferred lower plasma concentrations of growth factor (EGF), innate immunity markers (G-CSF, GM-CSF and IFN-α2), Th1 profile (IL-12[p70] and IL-15), Th17 profile (IL-17), Th2 profile (IL-5 and IL-13), inflammatory cytokines (TNF-β and IL-1β), and memory lymphocytes associated factor (IL-7). The gene discussed is IFNA2; the disease is tuberculosis.