performed omics analysis of CD4+T cell-derived exosomes from patients with rheumatoid arthritis (RA) and found that the expression of dihydropyrimidinase associated protein 3 (DPYSL3) was significantly up-regulated and the expression of proteasome activating complex subunit 1 (PSME1) was significantly down-regulated. This evidence concerns the gene DPYSL3 and rheumatoid arthritis.