reported the proteomic and lipidomic analysis of exosomes derived from ovarian cancer cells (SKOV-3) and ovarian surface epithelial cells (HOSEPiC) and found that Cholesterol Ester (ChE), Zymosterol (ZyE), V collagen alpha 2 chain (COL5A2) and lipoprotein lipase (LPL) than from HOSEPiC usually secrete body content is richer, therefore, outside the body protein and lipid secretion has certain application value in the early diagnosis of ovarian cancer (355). The gene discussed is COL5A2; the disease is ovarian carcinoma.