The results demonstrated that ADSCs-Exo could effectively restore the levels of miR-218 in breast cancer cells and significantly reduce the expression of miR-218 target genes (RUNX family transcription factor 2 [RUNX2] and RPTOR independent companion of MTOR complex 2 [RICTOR]) in breast cancer cells (MDA-MB-231). This evidence concerns the gene RUNX2 and breast cancer.