Studies have demonstrated that colony-stimulating factor 1 receptor (CSF-1R) inhibitor (PLX-3397) targeting the colony-stimulating factor 1/CSF1R (CSF1/CSF1R) signaling pathway can deplete tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells responsible for an immunosuppressive TME. Here, CSF1R is linked to neoplasm.