PTGS2 gene is an inducible immediate response gene, and its expression is rapidly upregulated by certain cytokines, growth factors, inflammatory mediators, pro-oncogenic factors and other stimulating factors during the occurrence of pathological responses such as inflammation or tumor, and its main product catalyzed by PG is an important inflammatory mediator in liver injury, which is an important link in inflammation (40). Here, PTGS2 is linked to neoplasm.