TNF and atherosclerosis: The signal pathways are complex, and the proteins related to the key targets in the I. chinensis were all marked red (Figure 5), such as Src, TNFα, ERK, AKT, CYP, etc. It could be seen from the figure that most of the proteins in this pathway were distributed in the middle reaches, and they had important effects on inflammatory reaction, foam cell formation, cytokines, inflammatory signals, plaque instability, etc. The study of this pathway is helpful for anti atherosclerosis.