EPCAM and neoplasm: The transmembrane glycoprotein CD326, also known as EpCAM (Epithelial Cell Adhesion Molecule), is predominantly expressed on normal epithelial cells and functions as a homotypic calcium-independent cell adhesion molecule. It plays crucial roles in tumor stem cells by promoting cell proliferation, inhibiting apoptosis (programmed cell death), and maintaining stem cell properties. This makes CD326 an important therapeutic target.