A cell adhesion molecule that specifically binds to laminin in the extracellular matrix and initiates the formation of semimembranous vesicles, thereby facilitating cellular migration and invasion, has been found to be closely associated with the proliferation, invasion, and metastasis of tumor stem cells. Integrin α6β4 interacts with the extracellular matrix, promoting survival and proliferation of tumor stem cells while aiding in evading immune system surveillance by tumor cells. This evidence concerns the gene LAMB2 and neoplasm.