SCD and neoplasm: The high level of UFA in CSCs has been demonstrated, and it has been shown that inhibiting the activities of SCD1 and acetaldehyde dehydrogenase 1A1 (ALDH1A1), or reducing the level of NF-κB in CSCs, can significantly decrease UFA content, diminish the stemness of CSCs, and impede tumor formation (Sun and Yang, 2019).