INS and type 2 diabetes mellitus: Based on the type 2 diabetes mellitus (T2DM) rat model established by HFD combined with streptozotocin (STZ) injection, 8 weeks of NXT gavage (1,000 mpk) was found to significantly ameliorate hyperlipidemia and hyperglycemia, improve insulin resistance, reduce inflammation and alleviate myocardial injury.