Thus, the viral oncoprotein may play a critical role in dynamically controlling the fate of host cells during the life cycle of viral infection by selectively inducing cleavage of AUKRA or AUKRB in response to intracellular and extracellular stress, and indicating that AURKA and AURKB undergo proteolytic cleavage at similar sites (Asp132 and Asp76) is fully precisely regulated at the post-translational level to mediate viral-mediated oncogenesis. Here, AURKB is linked to viral infectious disease.