Interestingly, interferon signal pathway-related genes lfit1, lfit3, Oas1a, Oas1b, Mx2 were of the top ten up-regulated genes in NLRP3 siRNA-treated osteoblasts, suggesting that interferon signal pathway may play an important role in NLRP3 siRNA attenuating osteoporosis. The gene discussed is NLRP3; the disease is osteoporosis.