Previous reports have demonstrated that NLRP3 inflammasome is critical in the development and progression of many metabolic diseases driven by chronic inflammation, including Alzheimer's disease, and diabetes 30, 31, and NLRP3 may contribute to bone loss caused by bacterial infection 10, but the effect of NLRP3 inflammasome on the pathology of PMOP remains poorly understood. The gene discussed is NLRP3; the disease is early-onset autosomal dominant Alzheimer disease.