STING1 and cancer: As a case in point, Mn2+ plays a crucial role in regulating the host's immune system 14, e.g., Mn2+ can promote dendritic cell (DC)-mediated cancer immunotherapy by stimulating the cGAS-STING (cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes) pathway 15.