For example, circ-CUX1 promotes the interaction between CUX1 and MYC-associated zinc finger protein (MAZ) by binding to EWS RNA-binding protein 1 (EWSR1), altering the transactivation of MAZ, the transcription of CUX1 and other genes related to tumor progression, and promoting tumor occurrence and invasion 47. Here, EWSR1 is linked to neoplasm.