Interestingly, we found that most of these ligands (e.g., CSF1, CXCL8, POSTN) 21, 32, 43 are broadly expressed in different glioma subclusters, whereas SPP1 is specifically expressed in the CEBPB+ GBM subcluster (Figure S14F). The gene discussed is CXCL8; the disease is central nervous system cancer.