SQSTM1 and familial pancreatic carcinoma: In line with these findings, we confirmed that p62-Keap1-Nrf2 axis was activated by PRMT6-mediated ADMA of p62, and suppression of p62 or Nrf2 could sensitized ferroptosis in pancreatic cancer (Figure 1A-D, Figure S1-2 and Figure S10-11).