There is evidence of increased inflammatory cytokines, interleukins (IL)-6, IL-8, IL-1 beta, and tumor necrosis factor-alpha (TNF-α) in the peripheral circulation of humans measured by serum assays following BD (10–12) suggesting that BD induces a systemic inflammatory response through physiological compensatory mechanisms and metabolic disruption. The gene discussed is IL6; the disease is Behcet disease.