Furthermore, inflammasome and IL-1 signaling are activated in senescent cells and IL-1a reproduces a senescent-associated secretory phenotype (SASP), suggesting that the spread of senescent cells from donor organs could not only induce immunogenicity but also accelerate aging in recipients, similar to the results from an experimental study in which senescent cells were observed surrounding a tissue adjacent to papilloma with p16Ink4a and p21Cip1 (40). Here, IL1A is linked to papilloma.