In a biased flow cytometry analysis, unsensitised HD patients had a reduction in Th1-like Tregs (p = 0.0026) and Teffs (p = 0.0085) and an increase in Th2-like Tregs (p = 0.0076) and Teffs (p = 0.005), due to a decrease in CXCR3 expression (p = 0.0030 and p = 0.0079, respectively) (Figure 3A for Tregs and Figure 4A for Teffs). Here, CXCR3 is linked to Huntington disease.