HOXA5 and hepatocellular carcinoma: In another paper by Jiehan et al., miRNA-130b-3p expression was shown to be significantly increased in HCC and downregulated its expression by directly targeting (Homeobox protein Hox-A5), which further activated the PI3K/AKT/mTORpathway, thereby stimulating HCC cells to induce capillary tube formation, endothelial cell migration, and proliferation (Li et al., 2023).