TARDBP and amyotrophic lateral sclerosis: The pathogenic proteins most commonly implicated in the accumulation of “misfolded” brain aggregates include, among the others, tau and β-amyloid in AD, α-synuclein in PD, huntingtin in HD and FUS, ZNF and TDP-43 in amyotrophic lateral sclerosis (ALS) and Fronto-Temporal Dementia (FTDs) (Jucker and Walker, 2018).