To this end, the effect of changes in protein neo-synthesis on HTT oligomerization could be also addressed in Tet on/Tet off inducible cell lines, like it has been previously shown for mutant alpha-synuclein, associated with Parkinson’s disease (Webb et al., 2003; Renna et al., 2011; Renna et al., 2013). This evidence concerns the gene SNCA and Parkinson disease.