Additionally, we have demonstrated that the number of samples with hypermethylated promoter of SFRP1 gene increased in glioblastomas (grade 4, p = 0.042) compared to lower grades, which is contrary to the present situation with SFRP4. Also contrary to the result of the present study, is the behavior of SFRP1. The gene discussed is SFRP1; the disease is glioblastoma.