Additionally, we have demonstrated that the number of samples with hypermethylated promoter of SFRP1 gene increased in glioblastomas (grade 4, p = 0.042) compared to lower grades, which is contrary to the present situation with SFRP4. Also contrary to the result of the present study, is the behavior of SFRP1. This evidence concerns the gene SFRP4 and glioblastoma.