Multiple studies have shown that SOX9 plays a key role in cell proliferation, invasion, EMT, and ECM deposition in various organ fibrosis and related diseases.17, 18, 19, 20, 21, 22, 23 Liu et al24 analyzed and compared the RNA-seq data at different time points from acute kidney injury (AKI) to chronic kidney injury and found that the expression level of SOX9 remained high, even a few weeks after AKI, indicating that SOX9 is not only involved in the repair process but also in chronic fibrosis. Here, SOX9 is linked to acute kidney injury.