ASXL1 and hyperinsulinemic hypoglycemia, familial, 4: In an effort to better specify the individual risk of progression for the patient, an NGS analysis was conducted, revealing a relatively small clone in ASXL1. Recent analyses showed that ASXL1 mutations are common in the premalignant state of GATA2 deficiency and that patients harboring these alterations have lower probabilities of survival (28, 29).