BCL2 and breast carcinoma: Upregulating anti-apoptotic proteins such as Bcl-2 and Bcl-XL, and downregulating or inactivating pro-apoptotic proteins such as Bax and Bak, has been confirmed to increase radiation resistance of malignant tumors, including breast cancer, lung cancer, mesothelioma, pancreatic cancer, to radiotherapy (36–41).