Autophagy, regenerative gene (REG) III expression, hinders DNA damage repair, G2/M arrest of the cell cycle, induces necrosis and aging, decreases Bax/Bcl-2 ratio and increases caspase 8 activity, affects oxidative cell metabolism, enhances the expression of apoptotic genes Bax, p53, and caspase 8, inhibits HIF-1α, inhibits angiogenesis, and induces anti-tumor immunity. This evidence concerns the gene HIF1A and neoplasm.