Autophagy, expression of Regenerating islet-derived protein III (REGIII), hinder DNA damage repair, cell cycle G2/M phase arrest, induce necrosis and senescence, decrease Bax/Bcl-2 ratio and enhance caspase 8 activity, impact oxidative cellular metabolism, enhance expression of apoptosis genes Bax, p53, caspase 8, inhibit HIF-1α, suppress angiogenesis, induce anti-tumor immunity. This evidence concerns the gene CASP8 and neoplasm.