BCL2 and neoplasm: Moreover, multiple signaling pathways contribute to the anti-tumor effects of Huangqin, such as NF-κB, Wnt/β-catenin, SATB1, Bcl-2 family proteins, Caspase, PI3K/Akt, mTOR, ERK, p38-MAPK, TGF-β/Smad, and Hippo/YAP pathways (95).