In this case report, the possible abscopal effect was described in a programmed death-ligand 1 (PD-L1)-negative recurrent esophageal squamous cell carcinoma patient with multiple lung metastases who was treated with an anti-PD-1 monoclonal antibody plus stereotactic body radiotherapy (SBRT). This evidence concerns the gene CD274 and esophageal squamous cell carcinoma.