(21), 31% (five out of 16) of HCC patients with low serum alpha-fetoprotein (AFP) levels (≤50 ng/mL) and those with tumors involving 50% or less of the liver demonstrated a sustained partial response to the regimen of intravenous 5-FU and subcutaneous rIFN-alpha-2b. Here, AFP is linked to hepatocellular carcinoma.