demonstrated that VEGF-A rs2010963 and VEGF-C rs4604006 were independent factors affecting PFS and OS when analyzing 148 samples (tumor or blood samples) from HCC patients treated with sorafenib and tested for VEGF-A, VEGF-C, and VEGFR-1, -2, and -3 SNPs (41). The gene discussed is VEGFA; the disease is hepatocellular carcinoma.