Furthermore, pembrolizumab, an anti-PD-L1 antibody, and nivolumab plus ipilimumab, a combination of anti-PD-L1 and anti-CTLA-4 antibodies, have also been approved for the first-line treatment of patients with locally unresectable or metastatic HCC (65, 66). Here, CD274 is linked to hepatocellular carcinoma.