Furthermore, for the first time, a recent study revealed ferroptosis upstream of immune cell activation and demonstrated that hepatocyte ferroptosis due to genetic GPX4 ablation causes a complex immune response that includes triggering CD8+ T-cell recruitment and inducing IFN-γ secretion by CD8+ T cells, which enhances PD-L1 expression on tumour cells. Here, GPX4 is linked to neoplasm.