For example, in anti-PD-L1 immunotherapy, IFN-γ secreted by activated CD8+ T cells downregulates the expression of SLC3A2 and SLC7A11, impairs the uptake of cystine by tumour cells, and consequently promotes ferroptosis-specific lipid peroxidation in tumour cells 47. This evidence concerns the gene SLC3A2 and neoplasm.