In addition, ABCC5, a member of the ATP-binding cassette (ABC) transporter family, and fibronectin type III domain containing 5 (FNDC5) can activate NRF2 through the PI3K/AKT pathway, which confers resistance to ferroptosis and reduces the anticancer activity of sorafenib in HCC cells 85,86. Here, NFE2L2 is linked to hepatocellular carcinoma.