Collectively, the restoration of SOAT1 expression in ETS1-knockdown OSCC cells recovered the decreased proliferation, tumor sphere formation, migration, and invasion abilities, as well as the inhibitory effects on lipid metabolism-related genes resulting from ETS1 knockdown, suggesting that ETS1 modulates lipid metabolism through SOAT1 and subsequently influences the progression of OSCC cells. Here, SOAT1 is linked to neoplasm.