CD4 and cancer: In detail, patients with low IRPI had higher proportions of cancer associated fibroblasts, macrophages, M1 macrophages, B cells, memory B cells, naïve B cells, class-switched memory B cells, myeloid dendritic cells, activated myeloid dendritic cells, plasmacytoid dendritic cells, CD4+ T cells (non-regulatory), effector memory CD4+ T cells, memory CD4+ T cells, CD8+ T cells, central memory CD8+ T cells and effector memory CD8+ T cells (Figure 3C).