Jaclyn Sceneay et al. found that compared with young mice and young patients with triple-negative breast cancer, aged mice and aged patients showed decreased IFN signaling with age; STING agonist could significantly improve response to immune checkpoint blockade therapy in aged mice, but no additive effect of STING agonist in young mice, although STING agonist could also activate IFN signaling in young mice 33. Here, STING1 is linked to triple-negative breast carcinoma.