Antonio Marzio et al. showed that mutations in KEAP1 induces stabilization of EMSY, which was responsible for the suppression of IFN signaling and immune evasion in non-small cell lung cancer; STING agonist could inhibit the growth of KEAP1-mutant tumors, but not KEAP1-widetype tumors 31. The gene discussed is STING1; the disease is non-small cell lung carcinoma.