P2X7R was an adenosine triphosphate (ATP)-gated ion channel, which can be activated by ATP and BzATP, etc. The P2X7R/NLRP3 pathway has been proven to promote GSDMD-NT-mediated cell pyroptosis to induce neuroinflammation in migraine, and inhibition of P2X7R was warranted for migraine treatment 11. Here, GSDMD is linked to migraine disorder.