In addition, USP2 expression was also found to be upregulated in the liver of fructose-containing (fructose-, palmitate-, and cholesterol-enriched, FPC) diet-induced MASLD mice, but not in a choline-methionine deficient diet (MCD)-induced MASLD mice (Fig. S3A). Here, USP2 is linked to metabolic dysfunction-associated steatotic liver disease.