ITGA5 and Parkinson disease: We looked examined gene expression in dissociated striatal tissue treated with MPTP to uncover putative cell adhesion molecules related with PD shown in Figure 1D. The expression of the integrin 5 (Itga5) gene was considerably reduced in MPTP-induced PD model mice compared to control mice, as measured by quantitative PCR and verified by western blotting and immunostaining (Fig.1E-1F).