Tenovin-1 is a potent inhibitor of SIRT1/2 deacetylating activity and an increase in SIRTs could not be a possible outcome as Tenovin-1's response to hepatic injury, the protective action of Tenovin-1 against hepatic fibrosis can be attributed to its reduction in SIRT1/2 activity. This evidence concerns the gene SIRT1 and Hepatic fibrosis.