CD274 and gastric cancer: Previously studies have shown that autophagy inhibition leads to the accumulation of P62/SQSTM1 and activation of NF-κB, wherein NF-κB inhibition or P62/SQSTM1 knockdown attenuates PD-L1 induction by autophagy inhibition, revealing that autophagy regulates PD-L1 expression in gastric cancer through the P62/SQSTM1-NF-κB pathway 34.