HK2 and cancer: Based on microarray data on the effect of CPSF6 on cancer metabolism and angiogenesis in CPSF6 depleted Hep3B cells, CPSF6 depletion suppressed glucose uptake, lactate and ATP, and lactate by ELISA and also attenuated the protein expression of HK2, PKM2, and LDH in Hep3B cells, indicating the potent role of CPSF6 in cancer metabolism and glycolysis, which is associated with the Warburg effect 46.