CPSF6 and hepatocellular carcinoma: CPSF6 depletion suppressed the viability and number of colonies, induced apoptosis via cleaved-PARP, and increased the sub-G1 population in Hep3B and Huh7 cells, indicating the cytotoxic and apoptotic effect of CPSF6 depletion in HCCs; this was supported by Tan et al.29 that CPSF6 is critically involved in HCC progression by upregulation of NAD(P)H quinone dehydrogenase 1(NQO1).