Ubiquitin specific protease 14 (USP14) is the only USP family that can reversibly bind to proteasome 19S regulatory particles and inhibit their degradation by removing the ubiquitin chain from the substrate.6 Studies have shown that the USP family is involved in different physiological processes in cells and in the occurrence of many cancers, including oral cancer,7 head and neck squamous cell carcinoma,8 and gastric cancer9. Here, USP14 is linked to cancer.