CIB1 and hepatocellular carcinoma: The study of CIB1 indicated that CIB1 can play a role in cell migration, proliferation and survival in cancer cell lines and in tumor growth in vivo in breast cancer.20 Researchers have also shown that CIB1 is essential for promoting HCC cell proliferation and that CIB1 levels in clinical liver cancer tissues are significantly higher than those in marginal tissues from the center of the tumor mass.21 In the tumor microenvironment, tumor growth and survival depend not only on carcinogenic signaling pathways but also on the formation of new blood vessels.