CIB1 plays a regulatory role in many cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy, and apoptosis.36, 37 Our results highlight the important role of CIB1 in influencing the resistance of HCC to lenvatinib. The gene discussed is CIB1; the disease is hepatocellular carcinoma.