,14 Based on the physiologic effects of this class of medications, there is also concern about the potential risk of acute kidney injury (AKI)17 and euglycemic diabetic ketoacidosis (DKA),8,11 particularly in patients with CKD given their predisposition to these complications (i.e., via suppressed repair19 and impaired insulin secretion,5,6 respectively) independent of SGLT2i. Here, INS is linked to acute kidney injury.