BRAF and osteoarthritis: Chondroitin-4-sulfate (CHSA), which is typically co-administered with glucosamine as a dietary supplement for osteoarthritis management, has been found to selectively enhance the tumor growth potential of BRAF V600E-expressing human melanoma cells in xenograft mice derived from patients or cell lines, as well as to impart resistance to BRAF inhibitors (Lin et al., 2018).