MAP: mean arterial pressure; UPCR: urine protein-to-creatinine ratio; AST: aspartate aminotransferase; ALT: alanine aminotransferase; ALP: alkaline phosphatase; WBC: White blood cell count; CKD: chronic kidney disease; eGFR: estimated glomerular filtration rate. The gene discussed is GPT; the disease is chronic kidney disease.