We observed that as compared to those in stage 1 CKD, patients in stage 4 CKD exhibited decreased serum albumin (3.08 ± 1.07 vs. 2.25 ± 1.03g/dL), total protein (6.09 ± 1.10 vs. 5.60 ± 1.08 g/dL) and hemoglobin (12.33 ± 2.25 vs. 10.31 ± 1.68) alongside increased urinary protein to creatinine ratio (UPCR) (1.76 (0.28 - 6.35) vs. 4.50 (2.25 - 9.75) mg/mg), blood urea (22 (19 - 28) vs. 84 (55 - 96) mg/dL), serum creatinine (0.91 (0.63 - 1.00) vs. 3.71 (2.16 - 4.36) mg/dL), and total cholesterol (284.50 (185 - 294) mg/dL) vs. 301 (182 - 406) mg/dL), with a persistent decline in eGFR. This evidence concerns the gene ALB and chronic kidney disease.