The recommended screening tool for pheochromocytoma is the measurement of urinary or plasma metanephrines; for endogenous cortisol secretion, the low-dose (1 mg) dexamethasone (DXM) overnight suppression test (ruled out if cortisol is below 1.8 ug/dL) is used [1], and for the suspicion of a mineralocorticoid excess, the plasma aldosterone concentration (PAC) (mg/dL) to plasma renin activity (PRA) (ng/mL/hour) ratio is used, with a value over 20 suggesting primary hyperaldosteronism [2]. The gene discussed is REN; the disease is Primary hyperaldosteronism.