It is worth noting that IL-6 and IL-1β have been shown to affect the pathophysiology of MDD by over-releasing corticotropin-releasing hormone and promoting glucocorticoid receptor resistance, which is likely to impair the negative feedback regulation of the HPA axis (33), and IL-6 may also activate the classical and trans-signaling pathways. The gene discussed is IL1B; the disease is major depressive disorder.