MAPT and early-onset autosomal dominant Alzheimer disease: Several rsfMRI studies observed that the AG showed atypically weak functional connectivity between the DMN and other brain regions.70,71 Research employing positron emission tomography reported hypometabolism, atrophy and amyloid and tau deposition in the parietal regions—including the AG—in individuals with Alzheimer’s disease.26,72-75 The current observation about the importance of the left AG in Alzheimer’s disease-related cognitive decline would fill a gap between AG anatomy and function and provide a more integrated view on the biological mechanisms underpinning Alzheimer’s disease.