These findings align with previous studies by Zhang et al., which highlighted curcumol-mediated inhibition of cholangiocarcinoma cell progression through CDKL3 knockdown [8], and Sun et al., whose research indicated that exosomal miRNA-205-5p from bone marrow mesenchymal stem cells could inhibit liver cancer, partially due to CDKL3 knockdown [19]. This evidence concerns the gene CDKL3 and cholangiocarcinoma.