Additionally, we discovered that chemotherapeutic agents such as cisplatin, docetaxel, cytarabine, gemcitabine, bleomycin, paclitaxel, rapamycin, and sunitinib had higher IC50 values in the lCDKL3 group, suggesting that CDKL3 could potentially serve as a marker for diagnosing and predicting prognosis in HCC patients. The gene discussed is CDKL3; the disease is hepatocellular carcinoma.