ANGPT2 and major depressive disorder: Based on our results, the expression of ANGPT2 has a low accuracy for the diagnosis of MDD (Figure 11C) and a certain degree of accuracy for the diagnosis of NP (Figure 11G); however, there are currently no studies related to ANGPT2 in NP or MDD, thus we are the first to discover that ANGPT2 may also play a key role in these diseases.