ANGPT2 and major depressive disorder: Similarly, as shown in Figures 12G–J, the expression of co-hub genes ANGPT2 (AUC = 0.609, Figure 12G), MMP9 (AUC = 0.578, Figure 12H), PLAU (AUC = 0.641, Figure 12I), and TIMP2 (AUC = 0.547, Figure 12J) all had low accuracy in diagnosing MDD in the GSE32280 dataset.