A strong correlation existed between the elevation of glial fibrillary acidic protein (GFAP)<sup>+</sup>/S100 calcium binding protein B (S100β)<sup>+</sup> enteric glial cells (EGCs) in inflamed colonic tissues and the disruption of the intestinal epithelial barrier (IEB) and gut vascular barrier (GVB) observed in chronic colitis. The gene discussed is S100B; the disease is Chronic colitis.