By contrast, results from murine models indicated that CMV infection with a high‐dosage (more than 1 × 104 PFU) not only provokes a rigorous anti‐viral response, but also sharply deflates circulating CD44lowCD62L+KLRG1−CD8+ TN cells and increases accumulation of CD8+ TE/M cells with CD44highCD62L−KLRG1+ phenotype.89, 117. The gene discussed is CD8A; the disease is cytomegalovirus infection.