In this large prospective series of colorectal cancer (CRC) patients, we (i) investigated the prognostic value of the Stroma AReactive Invasion Front Areas (SARIFA)-status (defined as the direct contact between a tumour gland/tumour cell cluster (≥5 cells) and adipocytes at the invasion front) and (ii) explored the relationship between Warburg-subtype (based on the expression of six glycolytic proteins and transcriptional regulators (GLUT1, PKM2, MCT4, PKM2, p53, PTEN), and H&Ebased SARIFA-status. The gene discussed is PKM; the disease is colorectal cancer.