LEP and lipodystrophy: Real-world data from the French National Lipodystrophy Reference Network also showed that 89% (n=8/9) of patients with PL who had baseline HbA1c levels > 8%, triglyceride levels > 5.6 mmol/L and serum leptin levels < 4 ng/ml responded to metreleptin with respect to glucose homeostasis or triglyceride levels compared with 61% (n=11/18) from the overall PL population [48].