LEP and lipodystrophy: The phenotypic heterogeneity of lipodystrophy, especially in PL, can further confound diagnosis, as many clinical characteristics overlap with normal variation (e.g., low body fat levels and musculature in male patients with PL, leptin levels in PL) or other disease phenotypes (e.g., fat accumulation on the face and neck resembling Cushing’s disease in PL) [3, 14, 34].