NR1H3 and psoriasis: However, steoryl-CoA-9-desaturase’s upstream activators such as the liver-X receptor-alpha and sterol regulatory element binding protein-1 have previously been reported to be downregulated in lesional psoriasis instead, highlighting the need to specifically determine the expression or activity of stearoyl-CoA-9-desaturase-1 in psoriasis (44, 45).